PKC Phosphorylation Regulates mGluR5 Trafficking by Enhancing Binding of Siah-1A
نویسندگان
چکیده
منابع مشابه
PKC phosphorylation regulates mGluR5 trafficking by enhancing binding of Siah-1A.
Glutamate is the major excitatory neurotransmitter in the mammalian CNS and acts on both ionotropic and metabotropic glutamate receptors (mGluRs). The mGluRs are widely distributed in the CNS and modulate a variety of neuronal processes, including neurotransmitter release and ion channel function. In hippocampus and cortex, mGluR5 is highly expressed and plays an important role in the regulatio...
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Metabotropic glutamate receptors (mGluRs) 1-8 are G protein-coupled receptors (GPCRs) that modulate excitatory neurotransmission, neurotransmitter release, and synaptic plasticity. PKC regulates many aspects of mGluR function, including protein-protein interactions, Ca(2+) signaling, and receptor desensitization. However, the mechanisms by which PKC regulates mGluR function are poorly understoo...
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Running title: PKC subtype-specific control of Ca 2+ oscillation receptor Total number of characters: 33,831-2-SUMMARY Prolonged activation of a metabotropic glutamate receptor, mGluR5a, causes synchronized oscillations in intracellular calcium, inositol 1,4,5-trisphosphate (IP 3) production, and protein kinase C (PKC) activation. Additionally, mGluR5 stimulation elicited cyclical translocation...
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STIMs (STIM1 and STIM2 in mammals) are transmembrane proteins that reside in the endoplasmic reticulum (ER) and regulate store-operated Ca(2+) entry (SOCE). The function of STIMs in the brain is only beginning to be explored, and the relevance of SOCE in nerve cells is being debated. Here we identify STIM2 as a central organizer of excitatory synapses. STIM2, but not its paralogue STIM1, influe...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1964-12.2012